The Liga Nacional de Ascenso de Honduras 2005-06 Apertura is the first part of the 2005-06 season in the Honduran second division of football. Atlético Olanchano, the champion of this tournament played against Deportivo Lenca, winners of the Clausura tournament for the promotion to First division.
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| Atlético Olanchano | 1 - 0 | Juticalpa Tulín | Catacamas |
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| Juticalpa Tulín | 1 - 0 | Atlético Olanchano | Juticalpa |
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| Penalties | ||||
| 2 - 3 |
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